Juxtaglomerular cells play an important role in the acute phase of hypertension in two-kidney Goldblatt hypertensive rats.
Answers are grounded in this paper and cite their sources.
May implicate juxtaglomerular cells in acute renovascular hypertension; hypothesis-generating in this rat model and leaves open clinical translation.
Clinical and pathological changes were investigated on acute phase in two-kidney Goldblatt hypertensive rats. Systolic blood pressure, plasma renin activity, plasma aldosterone and juxtaglomerular cell count (JGCC) increased slightly as early as 7 days after operation. Systolic blood pressure and plasma renin activity rose in the course of time after operation. Juxtaglomerular index (JGI) and JGCC of the clipped kidneys increased and JGI of the opposite kidneys decreased with the increase in systolic blood pressure. These results suggested that juxtaglomerular cells had an important role on acute phase in two-kidney Goldblatt hypertensive rats.
No takes yet. Share an insight, caveat, or question.
Yamakoshi et al. (1991) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: