January 1, 1982Clinical and Experimental Hypertension

Role of the Renin-Angiotensin-Aldosterone and Kallikrein-Kinin Systems in the Control of Fluid and Electrolyte Metabolism, Renal Function, and Arterial Blood Pressure

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Why the study?

Does captopril alter fluid and electrolyte metabolism, renal function, and arterial pressure in conscious sodium-deficient dogs?

Population

Conscious sodium-deficient dogs

Comparison

Captopril 20 mg/kg/day, followed by aldosterone… vs Untreated sodium-deficient state (baseline)

Design

Preclinical

Authors

RMRobert E. McCaaNewYork–Presbyterian Hospital

Discussion

Member takes

Implication

Supports angiotensin II dominance in natriuresis in sodium-deficient canine models; leaves open translation to human ACE inhibitor use.

Structured PICO

Does captopril alter fluid and electrolyte metabolism, renal function, and arterial pressure in conscious sodium-deficient dogs?

Population

Conscious sodium-deficient dogs

Intervention

Captopril 20 mg/kg/day, followed by aldosterone infusion or angiotensin II infusion (3 ng/kg/min)

Comparator

Untreated sodium-deficient state (baseline)

Outcome

Fluid and electrolyte metabolism, aldosterone secretion, renal function, and arterial pressuresurrogate

The long-term hypotensive and natriuretic actions of ACE inhibitors are mediated by the inhibition of angiotensin II formation, which is more potent than aldosterone in controlling sodium excretion.

Cite This Study

Robert E. McCaa (1982) studied this question.

synapsesocial.com/papers/6a815ab76a18bae044690d10 https://doi.org/10.3109/10641968209061627

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January 1, 1982Clinical and Experimental Hypertension

Role of the Renin-Angiotensin-Aldosterone and Kallikrein-Kinin Systems in the Control of Fluid and Electrolyte Metabolism, Renal Function, and Arterial Blood Pressure

View Full Paper

Ask AI

Bookmark

Why the study?

Does captopril alter fluid and electrolyte metabolism, renal function, and arterial pressure in conscious sodium-deficient dogs?

Population

Conscious sodium-deficient dogs

Comparison

Captopril 20 mg/kg/day, followed by aldosterone… vs Untreated sodium-deficient state (baseline)

Design

Preclinical

Authors

RMRobert E. McCaaNewYork–Presbyterian Hospital

Discussion

Member takes

Implication

Supports angiotensin II dominance in natriuresis in sodium-deficient canine models; leaves open translation to human ACE inhibitor use.

Structured PICO

Does captopril alter fluid and electrolyte metabolism, renal function, and arterial pressure in conscious sodium-deficient dogs?

Population

Conscious sodium-deficient dogs

Intervention

Captopril 20 mg/kg/day, followed by aldosterone infusion or angiotensin II infusion (3 ng/kg/min)

Comparator

Untreated sodium-deficient state (baseline)

Outcome

Fluid and electrolyte metabolism, aldosterone secretion, renal function, and arterial pressuresurrogate

The long-term hypotensive and natriuretic actions of ACE inhibitors are mediated by the inhibition of angiotensin II formation, which is more potent than aldosterone in controlling sodium excretion.

Cite This Study

Robert E. McCaa (1982) studied this question.

synapsesocial.com/papers/6a815ab76a18bae044690d10 https://doi.org/10.3109/10641968209061627

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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