Why the study?
The study sought to evaluate the accuracy of several anthropometric parameters in association with serum vitamin D levels and compare novel indices with conventional ones.
Are anthropometric indicators of adiposity associated with serum Vitamin D concentrations in adults without or with low-dose statin use?
Are anthropometric indicators of adiposity associated with serum Vitamin D concentrations in adults without or with low-dose statin use?
Novel and conventional anthropometric indices of adiposity, particularly Body Roundness Index and Waist to Height Ratio, are significantly associated with serum Vitamin D levels and deficiency.
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Should not yet alter vitamin D screening practices; hypothesis-generating for anthropometric indices in deficiency risk assessment.
This study sought to determine the accuracy of several anthropometric parameters in association with serum Vit. D concentrations and to compare the novel indices with the conventional ones. A total of 947 individuals referred to the cardiology clinic who have not used statin or take low-dose statin were evaluated through a cross-sectional study. Data on demographic information, anthropometric indices, and biochemical measurements were gathered using a checklist. Both the multivariable regression modeling and the area under the receiver-operating characteristic (ROC) were employed for the analysis. Considering novel indices, BRI (Body Roundness Index) showed the most powerful correlation with serum Vit. D levels among both genders. Among conventional ancient indices, WC (Waist Circumference) had the strongest association in both men and women groups. Based on the confounding factors-adjusted model, the highest odds ratio (OR) for the presence of Vit. D deficiency belonged to WHtR (Waist to Height Ratio) in women (OR, 0.347 (0.171–0.704), P = 0.003). None of the indices predicted Vit. D deficiency significantly among men. A Vit. D concentration of 4.55 ng/ml was found as a cutoff based on the metabolic syndrome status. The most powerful association with serum Vit. D levels were detected for BRI in both genders among newly developed indices. In addition, WHtR predicted Vit. D deficiency independent of confounding factors among women. • Body Roundness Index is the most powerful correlated novel parameter with serum Vit. D levels among both genders. • Among conventional indices, Waist Circumference had the strongest association in both men and women groups. • Waist to Height Ratio predicted Vit. D deficiency independent of age, triglyceride level, Fasting blood sugar, Systolic blood pressure, and supplement intake among women. • A Vit. D concentration of 4.55 ng/ml was found as a cutoff based on the presence of metabolic syndrome.
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Ashraf et al. (2024) studied this question.
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