Experimental study demonstrates direct 3-alkylation of coumarins via photoinduced electron transfer, highlighting an efficient route to functionalized coumarin derivatives.
A method for the direct 3‐alkylation of coumarins utilizing alkyl halides as the alkylating agents has been achieved. This versatile reaction is compatible with a range of alkyl halides, including activated alkyl bromides, perfluoroalkyl iodides, and unactivated alkyl iodides. We propose a mechanism involving photoinduced electron transfer between alkyl halides and coumarins in the first singlet excited (S 1 ) state, which generates alkyl radicals essential for the 3‐alkylation process.
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Cheng et al. (2025) studied this question.
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