Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interaction with adenosine A1-receptors.

Anesthetized dogs subjected to 60 minutes of left circumflex coronary artery (LCx) occlusion and 5 hours of reperfusion

Glyburide (5 micrograms/kg/min directly into the LCx) administered 20 minutes before ischemic preconditioning (5 minutes LCx occlusion followed by 10 minutes reperfusion) or before administration of the A1-agonist R-PIA (0.4 microgram/kg/min directly into the LCx)

Vehicle or sham preconditioning

Infarct sizesurrogate