Population
In vivo models and tissue culture for Coxsackievirus B3 infection
Comparison
Coxsackievirus B3 polymerase variants with… vs Wild-type (WT) Coxsackievirus B3
Design
Preclinical
Follow-up
30 days
Authors
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Supports error threshold for RNA virus fitness; leaves open whether modulating diversity limits cardiac tropism in vivo.
This study demonstrates that RNA viruses have an upper limit to mutability, where artificially increased genetic diversity reduces in vivo fitness and prevents persistent infection of organs like the heart.
Gnädig et al. (2012) studied this question.
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