Key result
Coxsackievirus B3 exhibits reduced mutational robustness relative to poliovirus, resulting in enhanced sensitivity to lethal mutagenesis by ribavirin.
Population
Coxsackievirus B3 (CVB3) and poliovirus (PV) in HeLa S3 cells
Comparison
Mutagenic nucleosides vs Poliovirus (PV) and untreated controls
Design
Preclinical
Authors
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May inform mutagenesis-based antivirals for enteroviruses; animal data leave open human translation.
Coxsackievirus B3 exhibits lower mutational robustness than poliovirus, making it more sensitive to lethal mutagenesis, which may inform antiviral strategies.
Graci et al. (2011) studied RNA virus infection (Coxsackievirus B3 and Poliovirus). Ribavirin and mutagenic nucleotides vs. Untreated virus / Poliovirus was evaluated on Specific infectivity and mutation frequency. Coxsackievirus B3 exhibits reduced mutational robustness relative to poliovirus, resulting in enhanced sensitivity to lethal mutagenesis by ribavirin.