Why the study?
Does plasma BNP measurement detect late cardiac dysfunction in children previously treated with anthracyclines?
Population
63 patients who had completed anthracycline therapy at least 1 year earlier.
Design
Cohort
Follow-up
at least 1 year post-therapy
Authors
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BNP may support detection of late anthracycline cardiotoxicity in survivors; leaves open its role as serial rather than standalone screen.
Does plasma BNP measurement detect late cardiac dysfunction in children previously treated with anthracyclines?
Plasma BNP is significantly elevated in anthracycline-treated children with late cardiac dysfunction, but considerable overlap between normal and abnormal groups suggests it may need further evaluation as a serial index rather than a standalone screening test.
Aggarwal et al. (2006) studied this question.
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