Why the study?
Do plasma ANP and BNP levels correlate with doxorubicin-induced cardiotoxicity in children with cancer?
Population
34 children (18 boys, 16 girls) who had previously received doxorubicin-containing chemotherapy for cancer.
Comparison
Measurement of plasma atrial natriuretic peptide… vs Healthy controls and patients with normal…
Design
Cross-sectional
Authors
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May support ANP/BNP as cardiotoxicity markers in children; hypothesis-generating and requires prospective validation before clinical adoption.
Do plasma ANP and BNP levels correlate with doxorubicin-induced cardiotoxicity in children with cancer?
Plasma ANP and BNP levels correlate with systolic dysfunction and may serve as markers for doxorubicin-induced cardiotoxicity in children.
Hayakawa et al. (2001) studied this question.
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