Key result
Doxorubicin-induced LV dysfunction in children is linked to ~145% higher NT-pro-BNP levels.
Why the study?
Do cardiac biomarkers (NT-pro-BNP, troponin T, CK-MB) correlate with subclinical left ventricular dysfunction in children treated with doxorubicin?
Population
30 children with cancer who received a cumulative dose of doxorubicin
Design
Cross-sectional
Authors
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Hypothesis-generating for NT-proBNP monitoring in pediatric doxorubicin therapy; prospective validation required before clinical adoption.
Cross-Sectional (n=30)
Do cardiac biomarkers (NT-pro-BNP, troponin T, CK-MB) correlate with subclinical left ventricular dysfunction in children treated with doxorubicin?
Absolute Event Rate: 363% vs 148%
p-value: p=0.012
NT-pro-BNP is a sensitive biomarker that correlates moderately with echocardiographic indices of left ventricular dysfunction, making it useful for monitoring early anthracycline-induced cardiotoxicity in children.
Pongprot et al. (2012) conducted a cross-sectional in Doxorubicin-induced cardiotoxicity in pediatric cancer (n=30). Left ventricular dysfunction vs. Normal left ventricular function was evaluated on NT-pro-BNP level (pg/mL) (p=0.012). NT-pro-BNP levels were significantly higher in children with doxorubicin-induced left ventricular dysfunction compared to those with normal function (363 vs 148 pg/mL; P=0.012).
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