Why the study?
Relationships between obesity and outcomes in pulmonary arterial hypertension are complex, with prior work suggesting obesity alongside PAH may associate with better survival.
Does obesity prior to PAH development affect survival in patients with pulmonary arterial hypertension?
Does obesity prior to PAH development affect survival in patients with pulmonary arterial hypertension?
Obesity prior to the development of PAH may be associated with worse survival, adding a temporal element to the obesity paradox.
Relationships between obesity and outcomes in pulmonary arterial hypertension (PAH) are complex. Previous work suggested obesity, occurring alongside PAH, may be associated with better survival. In our work, we suggest obesity prior to PAH development is associated with worse survival. This may add a novel temporal element to the "obesity-paradox."
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Oppegard et al. (2023) studied this question.
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