January 11, 2021StrokeOpen Access

Higher BMI was significantly associated with lower risks of the composite clinical outcome (HR 0.751, 95% CI 0.706-0.799), all-cause death (HR 0.658, 95% CI 0.605-0.716), major bleeding (HR 0.794, 95% CI 0.686-0.919), and ischemic stroke (HR 0.891, 95% CI 0.801-0.992).

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Why the study?

The influence of BMI on clinical outcomes in patients with AF remains controversial, particularly among Asian patients.

Does body mass index affect clinical outcomes in Asian patients with atrial fibrillation receiving oral anticoagulation?

Population

Asian patients with nonvalvular AF newly starting oral anticoagulation with available BMI data

Comparison

Clinical outcomes compared across BMI categories

Design

National database cohort study

Authors

SLSo‐Ryoung Lee ECEue‐Keun Choi JJJin‐Hyung Jung

Discussion

Member takes

Overview

Should not yet alter risk stratification by BMI in Asian AF on OAC; leaves open obesity paradox confirmation in prospective trials.

Structured PICO

Does body mass index affect clinical outcomes in Asian patients with atrial fibrillation receiving oral anticoagulation?

Population

Asian patients with nonvalvular atrial fibrillation who were new users of oral anticoagulants and had body mass index (BMI) information, identified from the Korean National Health Insurance database (2015-2017).

Intervention

Higher body mass index (BMI)

Comparator

Lower body mass index (underweight group)

Outcome

Ischemic stroke, intracranial hemorrhage, hospitalization for gastrointestinal bleeding, major bleeding, all-cause death, and composite clinical outcomehard clinical

In Asian patients with atrial fibrillation on oral anticoagulation, higher BMI is independently associated with lower risks of ischemic stroke, major bleeding, and all-cause mortality, demonstrating an obesity paradox.

Cite This Study

Lee et al. (2021) studied this question.

synapsesocial.com/papers/6a8171e961f3b0e3bec43913 https://doi.org/10.1161/strokeaha.120.030356

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January 11, 2021StrokeOpen Access

Higher BMI was significantly associated with lower risks of the composite clinical outcome (HR 0.751, 95% CI 0.706-0.799), all-cause death (HR 0.658, 95% CI 0.605-0.716), major bleeding (HR 0.794, 95% CI 0.686-0.919), and ischemic stroke (HR 0.891, 95% CI 0.801-0.992).

View Full Paper

Ask AI

Bookmark

Why the study?

The influence of BMI on clinical outcomes in patients with AF remains controversial, particularly among Asian patients.

Does body mass index affect clinical outcomes in Asian patients with atrial fibrillation receiving oral anticoagulation?

Population

Asian patients with nonvalvular AF newly starting oral anticoagulation with available BMI data

Comparison

Clinical outcomes compared across BMI categories

Design

National database cohort study

Authors

SLSo‐Ryoung Lee ECEue‐Keun Choi JJJin‐Hyung Jung

Discussion

Member takes

Overview

Should not yet alter risk stratification by BMI in Asian AF on OAC; leaves open obesity paradox confirmation in prospective trials.

Structured PICO

Does body mass index affect clinical outcomes in Asian patients with atrial fibrillation receiving oral anticoagulation?

Population

Intervention

Higher body mass index (BMI)

Comparator

Lower body mass index (underweight group)

Outcome

Ischemic stroke, intracranial hemorrhage, hospitalization for gastrointestinal bleeding, major bleeding, all-cause death, and composite clinical outcomehard clinical

Cite This Study

Lee et al. (2021) studied this question.

synapsesocial.com/papers/6a8171e961f3b0e3bec43913 https://doi.org/10.1161/strokeaha.120.030356

View Full Paper

Ask AI

Bookmark