Why the study?
Does angiotensin-(1-7) attenuate angiotensin II-induced reactive oxygen species stress-mediated injury in type 2 diabetic nephropathy?
Population
KK-A(y)/Ta mice (type 2 diabetic nephropathy model) and primary mesangial cells
Comparison
Angiotensin- co-administered with Angiotensin II vs Control group, Angiotensin II infusion alone…
Design
Preclinical
Authors
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May attenuate ANG II-mediated renal injury in diabetic models; leaves open the ACE2-ANG-(1-7)-Mas axis as a therapeutic target pending human studies.
Does angiotensin-(1-7) attenuate angiotensin II-induced reactive oxygen species stress-mediated injury in type 2 diabetic nephropathy?
Angiotensin-(1-7) attenuates angiotensin II-stimulated ROS-mediated injury in type 2 diabetic nephropathy, suggesting the ACE2-ANG-(1-7)-Mas receptor axis as a potential therapeutic target.
Moon et al. (2011) studied this question.
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