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December 15, 2014Clinical Science

Angiotensin-(1–7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice

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Why the study?

Does Angiotensin-(1-7) prevent systolic hypertension and kidney injury in Type 1 diabetic Akita mice?

Population

Male Type 1 diabetic Akita mice starting at 14 weeks of age

Comparison

Angiotensin- 500 μg/kg/day subcutaneously, with… vs Age-matched wild-type (WT) mice

Design

Preclinical

Follow-up

6 weeks (from 14 to 20 weeks of age)

Authors

YSYixuan ShiChinese Academy of Medical Sciences & Peking Union Medical CollegeCLChao‐Sheng LoMontreal Heart InstituteRPRanjit S. PaddaWestern University

Discussion

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Implication

Supports MasR agonism for diabetic nephropathy in mice; leaves open human translation.

Structured PICO

Does Angiotensin-(1-7) prevent systolic hypertension and kidney injury in Type 1 diabetic Akita mice?

P
Population
Male Type 1 diabetic Akita mice starting at 14 weeks of age
I
Intervention
Angiotensin-(1-7) 500 μg/kg/day subcutaneously, with or without MasR antagonist A779 (10 mg/kg/day), administered from 14 to 20 weeks of age
C
Comparator
Age-matched wild-type (WT) mice
O
Outcome
Systolic hypertension and kidney injury (urinary albumin/creatinine ratio, glomerular hyperfiltration, renal hypertrophy and fibrosis, and tubular apoptosis)surrogate

Angiotensin-(1-7) prevents systolic hypertension and diabetic nephropathy in a Type 1 diabetes mouse model via Mas receptor activation and reduction of oxidative stress.

Cite This Study

Shi et al. (2014) studied this question.

synapsesocial.com/papers/6a7c15fe01db1a7270ed45ebhttps://doi.org/10.1042/cs20140329

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy2005 · 304 citations
  2. 2Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice2011 · 63 citations
  3. 3Overexpression of Angiotensinogen Increases Tubular Apoptosis in Diabetes2007 · 85 citations
  4. 4Angiotensin-converting enzyme 2: implications for blood pressure and kidney disease2008 · 67 citations
  5. 5High Glucose Stimulates Angiotensinogen Gene Expression via Reactive Oxygen Species Generation in Rat Kidney Proximal Tubular Cells2002 · 184 citations