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May warrant bleeding-risk review before coprescribing in patients on other agents; leaves open causality and practice change.
WHAT IS ALREADY KNOWN ON THIS TOPIC Antidepressants might decrease platelet aggregation, while nonsteroidal anti-inflammatory drugs (NSAIDs) may also inhibit platelet function, so both may increase bleeding. 1 While antidepressants and NSAIDS are thought to increase gastrointestinal haemorrhage, 1 there are contradictory results on the risk of intracranial haemorrhage (ICH) with the coprescription of antidepressants and NSAIDs in case control and population studies. 2 3 Antidepressants alone are not thought to increase the risk of intracranial haemorrhage. 4
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Richard Morriss (2016) studied this question.
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