This study aims to investigate the frequency of the ACE I/D polymorphism and its correlation with clinicopathological characteristics in colorectal cancer patients in the Kashmiri population.
ACE I/D polymorphism frequency in Kashmiri colorectal cancer patients remains uncharacterized; leaves open ethnic-specific clinicopathological correlations.
Aims: The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different cancers and has been implicated as the risk factor for the development of various cancers. To investigate the ACE I/D genotype frequency in CRC cases in Kashmiri population and to correlate it with the known clinicopathological characters of CRC cases.
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A 2011 study studied this question.
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