Why the study?
Is the ACE gene insertion/deletion polymorphism associated with the development of renal cancer?
Is the ACE gene insertion/deletion polymorphism associated with the development of renal cancer?
The ACE gene I/D polymorphism does not appear to be associated with the development of renal cancer.
No association seen in this case-control study; leaves open whether other ACE variants influence renal cancer risk.
The angiotensin I-converting enzyme (ACE) contains an insertion/deletion (I/D) polymorphism, with the DD genotype associated with benign renal diseases. The distribution frequencies of the D and I alleles, and the DD, DI and II genotypes were determined in DNA extracted from kidney tissues of 58 renal cancer patients. The observed frequencies in patients who develop renal cancer was not significantly different than the normal population.
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Usmani et al. (2000) studied this question.
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