Why the study?
Does treadmill exercise alter antioxidant concentration and microalbuminuria in patients with intermittent claudication compared to controls?
Does treadmill exercise alter antioxidant concentration and microalbuminuria in patients with intermittent claudication compared to controls?
Treadmill exercise in claudicant patients leads to a transient decrease in antioxidant concentration that correlates with increased microalbuminuria, supporting the concept of ischemia-reperfusion injury.
Exercise-induced antioxidant drop may mark ischemia-reperfusion injury in claudication; hypothesis-generating for mechanistic or therapeutic studies.
Twenty male claudicant patients and nine age-matched controls were exercised on a treadmill. Blood and urine samples were taken before and after exercise. Total antioxidant concentration was measured using an enhanced chemiluminescent assay and microalbuminuria determined by radioimmunoassay. Claudicants had increased microalbuminuria after exercise. Mean (s.e.m.) antioxidant concentrations were similar for patients and controls at rest: 479(28) and 438(23) mumol/l respectively. Claudicants showed a significant decrease in antioxidant concentration 1 min after exercise to 428(27) mumol/l; this returned to 470(30) mumol/l by 10 min. A correlation was found between the decrease in antioxidant concentration and the increase in microalbuminuria (rs = -0.496, P < 0.05). This study supports the concept of ischaemia-reperfusion injury in claudicant patients and has implications for treatment.
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Khaira et al. (1995) studied this question.
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