Why the study?
Does ICD therapy prevent sudden death and improve overall survival compared to d,l-sotalol in patients with coronary artery disease and sustained VT/VF?
Population
100 patients with coronary artery disease and sustained ventricular tachycardia or fibrillation, mean age 58…
Comparison
Implantable cardioverter-defibrillators (ICDs) vs Oral d,l-sotalol (mean dose 438 +/- 95 mg/d)
Design
Case-control
Follow-up
3 years
Authors
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ICD may reduce sudden death and mortality versus sotalol in CAD with VT/VF; hypothesis-generating and requires randomized confirmation.
Does ICD therapy prevent sudden death and improve overall survival compared to d,l-sotalol in patients with coronary artery disease and sustained VT/VF?
ICD therapy is significantly more effective than electrophysiologically guided antiarrhythmic treatment with d,l-sotalol in preventing sudden death and reducing total mortality in patients with coronary artery disease and sustained VT/VF.
Haverkamp et al. (1996) studied this question.
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