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September 1, 2005Psychosomatic Medicine

Clinical Depression and Regulation of the Inflammatory Response During Acute Stress

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Why the study?

Does clinical depression alter the inflammatory response to acute psychological stress in women?

Population

n=72 women; half meeting diagnostic criteria for clinical depression, half with no history of psychiatric…

Comparison

17-minute mock-job interview vs Women with no history of psychiatric illness

Design

Case-control

Authors

GMGregory E. MillerNorthwestern UniversityNRNicolas RohlederFriedrich-Alexander-Universität Erlangen-NürnbergCSCinnamon StetlerFurman University

Discussion

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Implication

Depression may impair glucocorticoid regulation of inflammation during stress; leaves open contribution to cardiovascular risk in women.

Structured PICO

Does clinical depression alter the inflammatory response to acute psychological stress in women?

P
Population
n=72 women; half meeting diagnostic criteria for clinical depression, half with no history of psychiatric illness, matched for age and ethnicity
I
Intervention
17-minute mock-job interview (acute psychological stressor)
C
Comparator
Women with no history of psychiatric illness (healthy controls)
O
Outcome
Secretion and regulation of inflammatory molecules (monocytes, neutrophils, C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and sensitivity to glucocorticoids)surrogate

Clinical depression is associated with an impaired capacity to regulate inflammation during acute stress, which may contribute to excess morbidity and mortality.

Cite This Study

Miller et al. (2005) studied this question.

synapsesocial.com/papers/6a8177ecda9cafc35e33ad3ahttps://doi.org/10.1097/01.psy.0000174172.82428.ce
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pathways Linking Major Depression and Immunity in Ambulatory Female Patients1999 · 139 citations
  2. 2Five-Year Risk of Cardiac Mortality in Relation to Initial Severity and One-Year Changes in Depression Symptoms After Myocardial Infarction2002 · 736 citations
  3. 3Depression and Late Mortality After Myocardial Infarction in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) Study2004 · 292 citations
  4. 4The Pathophysiologic Roles of Interleukin-6 in Human Disease1998 · 1,164 citations
  5. 5National Institute of Mental Health Diagnostic Interview Schedule1981 · 5,282 citations