Changes in autonomic nervous function during the 4‐year follow‐up in middle‐aged diabetic and nondiabetic subjects initially free of coronary heart disease
Population
108 middle-aged subjects initially free of coronary heart disease, including control subjects, patients with…
Design
Cohort
Follow-up
4 years
Authors
Discussion
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Member takes
Implication
May warrant autonomic monitoring in non-insulin-dependent diabetes; hypothesis-generating and requires prospective validation.
Structured PICO
P
Population
108 middle-aged subjects initially free of coronary heart disease, including control subjects (n=44), patients with insulin-dependent diabetes mellitus (n=32), and patients with non-insulin-dependent diabetes mellitus (n=32).
C
Comparator
Nondiabetic control subjects
O
Outcome
Changes in autonomic nervous function score and heart rate variation during deep breathing over 4 yearssurrogate
In middle-aged subjects, autonomic nervous function deteriorates over 4 years primarily in those with non-insulin-dependent diabetes, driven by poor glycemic control.
Cite This Study
Mustonen et al. (1997) studied this question.