Experimental study demonstrates efficient two-step synthesis of indolizines via microwave irradiation, highlighting a rapid pathway for scaffold functionalization.
Readily accessible fused pyrrole scaffolds were further functionalized through a two-step sequence. In the first step, Vilsmeier–Haack formylation afforded the corresponding pyrrole aldehydes in good yields. Subsequently, these intermediates underwent annulation with a bromoallyl reagent under microwave irradiation to furnish indolizine derivatives.
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Grandecortes et al. (2026) studied this question.
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