What question did this study set out to answer?

Synthesize the biological roles of Type I, II, and III interferons in sepsis pathogenesis and evaluate their utility in patient stratification and precision immunotherapy.

August 16, 2026Seminars in Respiratory and Critical Care MedicineOpen Access

The Uncovered Role of Interferons in Sepsis: From Pathogenesis to Precision Immunotherapy

View Full Paper

Ask AI

Bookmark

Authors

CNCatherine M. NeumannFox Chase Cancer Center CPCécile PoulainInserm ARAntoine RoquillyInserm

Discussion

Member takes

Implication

Review highlights the dual role of interferons across sepsis stages, suggesting targeted interferon modulation as a viable precision immunotherapy strategy.

Key Points

Synthesize the biological roles of Type I, II, and III interferons in sepsis pathogenesis and evaluate their utility in patient stratification and precision immunotherapy.
Reviewed preclinical models and clinical studies examining interferon signaling pathways, immune endotypes, and organ failure mechanisms across different phases of sepsis.
Early interferon responses support pathogen clearance, but persistent or dysregulated signaling drives hyperinflammation, endothelial dysfunction, coagulopathy, and multiorgan failure.
Interferon-stimulated gene signatures and related biomarkers distinguish biologically distinct immune endotypes, supporting phase-specific and biomarker-guided immunomodulatory interventions.

Cite This Study

Neumann et al. (2026) studied this question.

synapsesocial.com/papers/6a8179dcf2fb91fc834ad423 https://doi.org/10.1055/a-2930-7367

View Full Paper

Ask AI

Bookmark

Implication

Review highlights the dual role of interferons across sepsis stages, suggesting targeted interferon modulation as a viable precision immunotherapy strategy.

The Uncovered Role of Interferons in Sepsis: From Pathogenesis to Precision Immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

The Uncovered Role of Interferons in Sepsis: From Pathogenesis to Precision Immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider