What question did this study set out to answer?

This review aims to summarize the role of interleukins (ILs) in sepsis and their potential as biomarkers and therapeutic targets.

November 19, 2025DiagnosticsOpen Access

The Interleukin Network in Sepsis: From Cytokine Storm to Clinical Applications

View Full Paper

Ask AI

Bookmark

Authors

MCMarcello Candelli MFMarta Sacco Fernandez GRGloria Rozzi

Discussion

Member takes

Implication

This review reveals the dual role of interleukins in sepsis as biomarkers and therapeutic targets, implying personalized medicine may enhance clinical outcomes.

Key Points

This review aims to summarize the role of interleukins (ILs) in sepsis and their potential as biomarkers and therapeutic targets.
Analyzed recent clinical and experimental studies focusing on various interleukins in sepsis.
Emphasized mechanistic insights, prognostic significance, and IL-targeted therapeutic strategies.
IL-6 was confirmed as a robust prognostic biomarker in sepsis.
IL-1 and IL-6 are key pro-inflammatory mediators amplifying vascular permeability and shock.
IL-10 emerged as an anti-inflammatory cytokine, limiting tissue injury but fostering immunosuppression.

Cite This Study

Candelli et al. (2025) studied this question.

synapsesocial.com/papers/6924f095c0ce034ddc350c66 https://doi.org/10.3390/diagnostics15222927

View Full Paper

Ask AI

Bookmark

Implication

This review reveals the dual role of interleukins in sepsis as biomarkers and therapeutic targets, implying personalized medicine may enhance clinical outcomes.

The Interleukin Network in Sepsis: From Cytokine Storm to Clinical Applications

Discussion

Member takes

Implication

Key Points

Cite This Study

The Interleukin Network in Sepsis: From Cytokine Storm to Clinical Applications

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider