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August 16, 2026CancersOpen Access

Oligometastatic GIST: Impact of Treatment Modalities and Metastatic Distribution on Overall Survival

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Authors

HPHayes PearceNSNikita SharmaLSL. Simonelli

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Overview

Retrospective cohort study demonstrates improved overall survival with cytoreductive surgery plus systemic therapy in oligometastatic GIST, indicating substantial benefit from surgical intervention.

Key Points

  • To evaluate clinical outcomes, metastatic distribution, and the therapeutic impact of cytoreductive surgery on overall survival in patients with oligometastatic gastrointestinal stromal tumors.
  • Retrospective review of N=96 patients with biopsy-proven oligometastatic GIST (≤5 lesions confined to a single organ) from a prospectively maintained institutional database between August 1998 and June 2025.
  • Overall survival was estimated using Kaplan–Meier analysis and compared via log-rank tests and Cox proportional hazards regression models.
  • Cytoreductive surgery combined with systemic therapy significantly prolonged median overall survival compared to systemic therapy alone (10.8 vs. 7.4 years; HR: 0.44; 95% CI, 0.22–0.89; p = 0.019).
  • Overall survival did not significantly differ between patients with liver versus peritoneal metastases (HR: 1.27; 95% CI, 0.59–2.70; p = 0.540) or Hispanic versus non-Hispanic ethnicity (HR: 0.81; 95% CI, 0.34–1.90; p = 0.624).

Cite This Study

Pearce et al. (2026) studied this question.

synapsesocial.com/papers/6a8179dcf2fb91fc834ad50ahttps://doi.org/10.3390/cancers18162622
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Also Consider

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  1. 1Prognostic Impact of Metastasis Timing in Metastatic Gastrointestinal Stromal Tumors: A Multicenter Retrospective Cohort Study2026
  2. 2Survival outcomes and prognostic factors of advanced gastrointestinal stromal tumors: in the era of multiple tyrosine kinase inhibitors2024 · 2 citations
  3. 3Factors Influencing Survival After Curative Gastrectomy in Oligometastatic Gastric Cancer: A Single-Center Study2026
  4. 4Prognostic Factors for Survival in Surgically Treated Patients with Gastrointestinal Stromal Tumors: A Single-Center 15-Year Retrospective Analysis2026
  5. 5Unusual metastatic patterns in gastrointestinal stromal tumors: a multicenter analysis from the Dutch GIST Registry2026