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August 16, 2026Peritoneal Dialysis InternationalOpen Access

Peritoneal effluent-derived mononuclear phagocyte immune profiles may relate to cardiac function in peritoneal dialysis

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Authors

MKMicky KarstenNHNico HahnPVPuck Vree

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Overview

Cross-sectional study links higher peritoneal monocyte-to-dendritic cell ratios with cardiac strain in peritoneal dialysis, suggesting local immune contributions to heart dysfunction.

Key Points

  • To investigate peritoneal mononuclear phagocyte phenotypes and determine whether they associate with systemic inflammation and cardiac function in peritoneal dialysis patients.
  • Characterized patient-matched peripheral blood and peritoneal dialysis effluent (PDE) cells from 13 adult patients using mononuclear phagocyte-selective flow cytometry and unbiased clustering.
  • Correlated left ventricular global longitudinal strain (LV-GLS) with PDE immune profiles and serum inflammatory markers in a cohort of 21 peritoneal dialysis patients.
  • Mononuclear phagocytes predominated in PDE and displayed a more differentiated phenotype than blood-derived counterparts, with substantial overlap in classical monocyte clusters.
  • A higher PDE-derived differentiated monocyte-to-dendritic cell ratio and reduced peritoneal monocyte antigen-presenting capacity correlated with more impaired LV-GLS.
  • Circulating systemic inflammatory markers were largely undetectable in this stable peritoneal dialysis cohort.

Cite This Study

Karsten et al. (2026) studied this question.

synapsesocial.com/papers/6a8179eff2fb91fc834ad6fbhttps://doi.org/10.1177/08968608261476527
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