The relationship between changes in peritoneal membrane solute transfer characteristics and cardiac remodeling in patients with peritoneal dialysis

Introduction We aimed to determine the relationship between the dilatation of the heart chambers and the change in peritoneal membrane solute transfer characteristics (PMTC) in long‐term peritoneal dialysis (PD) patients. Methods This is a retrospective, single‐center study including the follow‐up of maintenance PD patients. According to the changes in PMTC from baseline to the last visit, patients were divided into three groups; stable ( n = 11), increased ( n = 41), and decreased transporters ( n = 35). Results Left atrium (LA) and Right ventricle (RV) dilatation were more prominent in the PMTC‐decreased group compared to PMTC‐increased and stable groups ( p < 0.001 and p = 0.07, respectively). The Cox regression analysis showed that only decreased PMTC was associated with LA dilatation (HR 2.89 [CI 95%1.54, 5.45] p < 0.01) and RV dilatation (HR 3.01 [CI 95%1.40, 6.21] p < 0.01). Conclusion PD can be associated with unfavorable dynamic changes in cardiac structure and functions even at the subclinical level.