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March 25, 2010Peritoneal Dialysis International

Aggressive treatment based on plasma ANP and LAD in peritoneal dialysis patients significantly reduced left atrial diameter from 36 mm to 33 mm over 24 months (p<0.05).

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Why the study?

Does aggressive treatment based on ANP and LAD monitoring improve cardiac structure and function in peritoneal dialysis patients?

Population

32 peritoneal dialysis (PD) patients in Juntendo University Hospital, Tokyo

Design

Cohort

Follow-up

24 months

Key result

Aggressive treatment based on plasma ANP and LAD in peritoneal dialysis patients significantly reduced left atrial diameter from 36 mm to 33 mm over 24 months (p<0.05).

Authors

HIHiroaki IoYRYuuki RoYSYoshimi Sekiguchi

Discussion

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Member takes

Overview

May support ANP/LAD-guided volume management in PD; leaves open need for RCTs on outcomes.

Study Design

Type

Cohort (n=32)

Multicenter

No

Structured PICO

Does aggressive treatment based on ANP and LAD monitoring improve cardiac structure and function in peritoneal dialysis patients?

P
Population
32 peritoneal dialysis patients undergoing aggressive treatment based on plasma ANP and LAD, followed prospectively for 24 months.
E
Exposure
Longitudinal monitoring of echocardiography parameters and plasma ANP, with aggressive treatment including angiotensin type 1 receptor blocker for BP <140/90 mmHg, recombinant human erythropoietin for Hb 10.0 g/dL, and diuretics/fluid restriction if ANP >43.0 pg/mL or LAD >39 mm
O
Outcome
Changes in left atrial diameter (LAD), left ventricular mass index (LVMI), ejection fraction, and plasma ANP levels at 0, 6, 12, 18, and 24 monthssurrogate

Main Result

p-value: p=<0.05

Aggressive volume and blood pressure management guided by ANP and echocardiography preserves left ventricular structure and function in peritoneal dialysis patients over 24 months.

Cite This Study

Io et al. (2010) conducted a cohort in Peritoneal dialysis (n=32). Aggressive treatment based on plasma ANP and LAD was evaluated on Left atrial diameter (LAD) (p=<0.05). Aggressive treatment based on plasma ANP and LAD in peritoneal dialysis patients significantly reduced left atrial diameter from 36 mm to 33 mm over 24 months (p<0.05).

synapsesocial.com/papers/6a20bf956aba112f1d33798bhttps://doi.org/10.3747/pdi.2009.00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nonparallel Progression of Left Ventricular Structure and Function in Long-Term Peritoneal Dialysis Patients2017 · 21 citations
  2. 2Cardiac geometry, function, and remodeling patterns in patients under maintenance hemodialysis and peritoneal dialysis treatment2021 · 14 citations
  3. 3A longitudinal study of cardiac structure and function using echocardiography in patients undergoing peritoneal dialysis2021 · 10 citations
  4. 4Effect of Peritoneal Dialysis Treatment on Left Ventricular Systolic and Diastolic Functions in Patients with End-Stage Renal Disease2014
  5. 5Comparison of Ventricular and Atrial Geometry and Functions in Dialysis Patients2024