Why the study?
Peritoneal dialysis can be associated with abnormal cardiac structure and function and increased mortality risk, but the dynamic echocardiographic changes during the first 2 years of therapy and their links to mortality needed evaluation.
Does peritoneal dialysis affect cardiac structure and function over 2 years in patients with end-stage renal disease?
Population
72 ESRD patients starting PD
Comparison
Echocardiographic parameters at baseline vs year 1 and year 2
Design
Longitudinal cohort study
Follow-up
2 years
Key result
Every 1% increase in right ventricular diameter during the first 2 years of peritoneal dialysis was associated with a 68.2% higher risk of all-cause mortality (HR 1.682).
Authors
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RV enlargement on PD was associated with higher mortality; leaves open whether echocardiography-guided interventions improve survival.
Cohort (n=72)
No
Does peritoneal dialysis affect cardiac structure and function over 2 years in patients with end-stage renal disease?
Hazard Ratio: 1.682 (95% CI 1.017–2.783)
p-value: p=0.043
In patients undergoing peritoneal dialysis, right ventricular diameter significantly increases over the first 2 years, and this structural deterioration is associated with a higher risk of all-cause mortality.
Zhu et al. (2021) conducted a cohort in End-stage renal disease (ESRD) undergoing peritoneal dialysis (n=72). Increase in right ventricular diameter (RVD) vs. No increase or lesser increase in RVD was evaluated on All-cause mortality risk associated with echocardiographic parameter changes (HR 1.682, 95% CI 1.017-2.783, p=0.043). Every 1% increase in right ventricular diameter during the first 2 years of peritoneal dialysis was associated with a 68.2% higher risk of all-cause mortality (HR 1.682).
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