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August 16, 2026BMC OphthalmologyOpen Access

Predictors of 1-year fibrosis in treatment-naïve neovascular age-related macular degeneration: the role of baseline OCTA-derived MNV vessel density

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Authors

YLYi LinXZXianggui ZhangZHZhen Huang

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Overview

Retrospective study finds baseline microvascular density predicts one-year fibrosis in neovascular age-related macular degeneration, highlighting advanced imaging for patient risk stratification.

Key Points

  • To evaluate whether baseline and post-loading optical coherence tomography angiography (OCTA) metrics, particularly macular neovascularization (MNV) vessel density, independently predict 1-year fibrosis in treatment-naïve neovascular age-related macular degeneration (nAMD).
  • Retrospective, single-center study analyzing 88 eyes from 72 treatment-naïve patients with type 1 or 2 MNV receiving a 3 + PRN anti-VEGF loading regimen with ≥12 months follow-up.
  • High-quality OCTA imaging assessed quantitative MNV parameters (fractal dimension, branch points, endpoints, segments, vessel density) at baseline and post-loading visits within 1 week of the third injection.
  • At 1 year, 31 eyes developed fibrosis and 57 did not, with the fibrosis group presenting higher baseline MNV vessel density and significantly elevated post-loading fractal dimension, branch points, endpoints, segments, and vessel density.
  • Multivariable logistic regression showed baseline best-corrected visual acuity (OR 1.162, 95% CI 1.024–1.319; P = 0.020), central macular thickness (OR 1.032, 95% CI 1.001–1.064; P = 0.043), and MNV vessel density (OR 1.073, 95% CI 1.009–1.142; P = 0.025) independently predicted 1-year fibrosis, yielding a combined model AUC of 0.787 (95% CI 0.688–0.874).

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6a817a01f2fb91fc834ad8b8https://doi.org/10.1186/s12886-026-05089-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Baseline OCT Biomarkers Associated with the 2-year Development of Macular Atrophy or Fibrosis in Neovascular AMD2026 · 2 citations
  2. 2Quantitative Features of Neovascularization in Fibrotic Age-Related Macular Degeneration and Their Associations With Visual Changes After a Single Anti-VEGF Therapy2026
  3. 3Neovascular Age-Related Macular Degeneration Treated with Aflibercept: Five-Year Follow-Up and Correlation with Optical Coherence Tomography Biomarkers in a Real-World Setting2025 · 1 citations
  4. 4Impact of Macular Neovascularization Architecture in Age-Related Macular Degeneration on Treatment Requirement During the First 5 Years of Treatment2026
  5. 5Imaging and functional correlates of fibrosis in neovascular age-related macular degeneration: a systematic review2026