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August 16, 2026Seminars in Dialysis

Depression affects ~46% of hemodialysis patients, with higher rates in those under 40.

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Why the study?

Depression is prevalent in hemodialysis patients, but reported prevalence varies greatly across different regions.

Population

21,608 hemodialysis patients across 137 cross-sectional studies

Design

Meta-analysis of cross-sectional studies

Key result

The pooled prevalence of depression among hemodialysis patients was 45.8% (95% CI: 42.0%-49.6%), with higher rates observed in patients under 40 years old.

Authors

YLYang LiCross-Cutting CardiologyYLYu LiuXiangyang Hospital of Traditional Chinese MedicineSWSiyu WuHubei University of Arts and Science

Discussion

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Overview

Supports routine depression screening in hemodialysis patients; extends regional prevalence estimates globally.

Key Points

  • To determine the global prevalence of depression among patients undergoing hemodialysis and identify factors driving variation across different regions and populations.
  • Systematic search of PubMed, Embase, Cochrane Library, and Web of Science databases from inception to July 2023.
  • Included 137 cross-sectional studies covering 21,608 hemodialysis patients, analyzing pooled prevalence via random-effects models, subgroup analyses, and meta-regression.
  • The overall pooled prevalence of depression in hemodialysis patients was 45.8% (95% CI: 42.0%-49.6%).
  • Prevalence was lowest in high-income countries at 38.9% (95% CI: 34.1%-43.7%) and highest in patients younger than 40 years at 50.8% (95% CI: 25.6%-76.0%).
  • Higher proportions of female patients and the choice of depression self-rating scales significantly contributed to heterogeneity in observed prevalence rates.

Study Design

Type

Meta-Analysis (n=21,608)

Structured PICO

P
Population
21,608 hemodialysis patients from 137 cross-sectional studies assessed for the prevalence of depression.
O
Outcome
Prevalence of depressionpatient reported

Depression is highly prevalent in hemodialysis patients, affecting nearly half of the population, highlighting the need for routine screening and intervention.

Cite This Study

Li et al. (2026) conducted a meta-analysis in Depression in hemodialysis patients (n=21,608). Hemodialysis was evaluated on Prevalence of depression (95% CI 42.0%-49.6%). The pooled prevalence of depression among hemodialysis patients was 45.8% (95% CI: 42.0%-49.6%), with higher rates observed in patients under 40 years old.

synapsesocial.com/papers/6a817a01f2fb91fc834ad8f0https://doi.org/10.1111/sdi.70043
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A cross-sectional study on assessing depression among hemodialysis patients2022 · 10 citations
  2. 2Prevalence and predictors of depression among hemodialysis patients: a prospective follow-up study2019 · 115 citations
  3. 3Prevalence, Predictors, and Challenges in the Management of Depression Among Patients on Hemodialysis in the Arab Countries: A Systematic Review2026
  4. 4Assessment of sociodemographic determinants of depression among patients on hemodialysis.2020 · 1 citations
  5. 5Repeated measurements of depression and outcomes in patients receiving hemodialysis †2022