Why the study?
Depression appears common in end-stage renal disease, but the changes in depression over time and its impact on outcomes needed evaluation.
Does baseline depression predict mortality in patients receiving maintenance hemodialysis?
Population
317 patients receiving hemodialysis from two hospitals
Comparison
Depression levels assessed by Hamilton Depression Scale over time
Design
Longitudinal study
Follow-up
2 years
Key result
Higher baseline depression scores were significantly associated with increased mortality in patients receiving hemodialysis, with the relative risk of death increasing by 1.069 for each point increase in the Hamilton Depression Scale score.
Authors
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May identify high-risk hemodialysis patients via depression screening; leaves open whether treatment improves survival.
Cohort (n=317)
Yes
Does baseline depression predict mortality in patients receiving maintenance hemodialysis?
Relative Risk: 1.069 (95% CI 1.005–1.138)
p-value: p=0.034
Baseline depression is an independent predictor of mortality in patients receiving maintenance hemodialysis, emphasizing the importance of psychological screening and management in this population.
Zhang et al. (2022) conducted a cohort in End-stage renal disease receiving maintenance hemodialysis (n=317). Depression (HAMDS score) vs. Lower depression score was evaluated on Mortality (RR 1.069, 95% CI 1.005-1.138, p=0.034). Higher baseline depression scores were significantly associated with increased mortality in patients receiving hemodialysis, with the relative risk of death increasing by 1.069 for each point increase in the Hamilton Depression Scale score.
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