Key result
Higher baseline depression scores were associated with increased mortality in patients receiving hemodialysis, with the relative risk of death increasing by 1.069 for each point increase in the Hamilton Depression Scale score.
Why the study?
Depression appears common in end-stage renal disease, but the changes in depression over time and its impact on outcomes needed evaluation.
Does baseline depression predict mortality in patients receiving maintenance hemodialysis?
Cohort (n=317)
Yes
Does baseline depression predict mortality in patients receiving maintenance hemodialysis?
Baseline depression is an independent predictor of mortality in patients receiving maintenance hemodialysis, emphasizing the importance of psychological screening and management in this population.
Answers are grounded in this paper and cite their sources.
May identify high-risk hemodialysis patients via depression screening; leaves open whether treatment improves survival.
Objective: Depression appears to be common among the patients with end-stage renal disease (ESRD). Therefore, how to comprehensively analyze the changes in depression and its impact on patient outcomes is an important research direction. The objectives of this study were to assess changes in depression and whether depression can be used to predict outcomes in patients receiving hemodialysis. Methods: In a longitudinal study, 317 patients receiving hemodialysis from two hospitals were investigated. Depression was assessed using the Hamilton Depression Scale (HAMDS) at baseline. Outcomes data (survival and mortality) were collected from baseline to the end of follow-up 2 years later. Mortality was assessed using Cox proportional hazards analysis. Results: The HAMDS score and percentage of high scores increased at three time points. Moreover, the changes were statistically significant. Surviving patients had significantly lower HAMDS scores. Through multivariate Cox regression analysis, age and depression can be used to predict mortality ( P < 0.05), and the relative risks (RRs) were 1.032 and 1.069, respectively. Conclusions: Depression in patients receiving hemodialysis is worse. Moreover, baseline depression is an independent predictor of outcomes. Patients receiving hemodialysis should be focused on improving their psychological complications. A systematic and individual psychological health promotion plan must also be incorporated into the health education plan for patients receiving hemodialysis.
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Zhang et al. (2022) conducted a cohort in End-stage renal disease receiving maintenance hemodialysis (n=317). Depression (HAMDS score) vs. Lower depression score was evaluated on Mortality (RR 1.069, 95% CI 1.005-1.138, p=0.034). Higher baseline depression scores were associated with increased mortality in patients receiving hemodialysis, with the relative risk of death increasing by 1.069 for each point increase in the Hamilton Depression Scale score.
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