Key result
Among hospitalized hemodialysis patients, depression was associated with a decreased risk of in-hospital mortality but an increased rate of adverse effects in discharged patients.
Why the study?
Does depression affect in-hospital mortality and adverse effects in hospitalized patients with ESRD on hemodialysis?
Observational
Yes
Does depression affect in-hospital mortality and adverse effects in hospitalized patients with ESRD on hemodialysis?
In hospitalized hemodialysis patients, depression is associated with a paradoxical decrease in in-hospital mortality but an increase in adverse effects post-discharge.
Answers are grounded in this paper and cite their sources.
Depression-linked lower in-hospital mortality in hemodialysis patients should not change practice; leaves open confounding and post-discharge risks for prospective study.
BACKGROUND/AIMS: Depression is common in patients with end-stage renal disease (ESRD) on hemodialysis (HD). Although, depression is associated with mortality, the effect of depression on in-hospital outcomes has not been studied as yet. METHODS: We analyzed the National Inpatient Sample for trends and outcomes of hospitalizations with depression in patients with ESRD. RESULTS: The proportion of ESRD hospitalizations with depression doubled from 2005 to 2013 (5.01-11.78%). Hospitalized patients on HD with depression were younger (60.47 vs. 62.70 years, p < 0.0001), female (56.93 vs. 47.81%, p < 0.0001), white (44.92 vs. 34.01%, p < 0.0001), and had higher proportion of comorbidities. However, there was a statistically significant lower risk of mortality in HD patients within the top 5 reasons for admissions. CONCLUSION: There were significant differences in demographics and comorbidities for hospitalized HD patients with depression. Depression was associated with an increased rate of adverse effects in discharged patients, and decreased in-hospital mortality.
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Chan et al. (2017) conducted an observational in End-stage renal disease on hemodialysis. Depression vs. No depression was evaluated on In-hospital mortality. Among hospitalized hemodialysis patients, depression was associated with a decreased risk of in-hospital mortality but an increased rate of adverse effects in discharged patients.
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