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June 24, 2021Clinical Kidney JournalOpen Access

Depression screening and clinical outcomes among adults initiating maintenance hemodialysis

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Key result

Pre-ESRD depression screening was associated with a lower risk of all-cause mortality (HR 0.94; 95% CI 0.90-0.99) and hospitalization during the 12 months post-transition to hemodialysis.

Why the study?

Does depression screening in the year prior to hemodialysis initiation reduce mortality and hospitalization in adults transitioning to maintenance hemodialysis?

Population

30,013 Veterans with end-stage renal disease (ESRD) transitioning to maintenance hemodialysis

Comparison

Depression screening in the year prior to… vs No depression screening in the year prior to…

Design

Cohort

Follow-up

12 months post-transition

Authors

MFMichael J. FischerUniversity of GrazESElani StrejaUniversity of California, IrvineJHJui‐Ting HsiungUniversity of California, Los Angeles

Discussion

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Implication

Pre-HD depression screening was associated with better outcomes; leaves open whether routine screening improves post-initiation prognosis in ESRD.

Study Design

Type

Cohort (n=30,013)

Multicenter

Yes

Structured PICO

Does depression screening in the year prior to hemodialysis initiation reduce mortality and hospitalization in adults transitioning to maintenance hemodialysis?

P
Population
30,013 Veterans with end-stage renal disease transitioning to maintenance hemodialysis, followed for 12 months post-transition.
E
Exposure
Depression screening in the year prior to hemodialysis initiation
C
Comparator
No depression screening in the year prior to hemodialysis initiation
O
Outcome
All-cause mortality and hospitalization during the 12 months post-transitionhard clinical

Main Result

Hazard Ratio: 0.94 (95% CI 0.9–0.99)

Absolute Event Rate: 0.32% vs 0.35%

Depression screening prior to maintenance hemodialysis transition is associated with lower mortality and hospitalization rates in the following year.

Cite This Study

Fischer et al. (2021) conducted a cohort in End-stage renal disease (n=30,013). Depression screening vs. No depression screening was evaluated on All-cause mortality (HR 0.94, 95% CI 0.90-0.99). Pre-ESRD depression screening was associated with a lower risk of all-cause mortality (HR 0.94; 95% CI 0.90-0.99) and hospitalization during the 12 months post-transition to hemodialysis.

synapsesocial.com/papers/6ab8c18f6c320cb786b082ddhttps://doi.org/10.1093/ckj/sfab097
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dialysis Provider and Outcomes among United States Veterans Who Transition to Dialysis2018 · 23 citations
  2. 2Pre-ESRD Depression and Post-ESRD Mortality in Patients with Advanced CKD Transitioning to Dialysis2017 · 42 citations
  3. 3Depressive affect in incident hemodialysis patients2017 · 9 citations
  4. 4Association of Depression and Antidepressant Use with Mortality in a Large Cohort of Patients with Nondialysis-Dependent CKD2012 · 49 citations
  5. 5Associations of Depressive Symptoms and Pain with Dialysis Adherence, Health Resource Utilization, and Mortality in Patients Receiving Chronic Hemodialysis2014 · 151 citations