Key result
Baseline depression in hemodialysis patients was associated with an increased risk of all-cause mortality (HR 1.51; 95% CI 1.06-2.17), which attenuated after adjusting for comorbidities.
Why the study?
Are depression symptoms associated with increased all-cause mortality in patients receiving maintenance hemodialysis?
Population
323 patients receiving maintenance hemodialysis, mean age 62.9, 46% women, 22% African-American.
Comparison
Depression symptoms vs No depression symptoms (CES-D score <16)
Design
Cohort
Follow-up
median 25 months
Authors
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Highlights potential prognostic role of depression in hemodialysis; leaves open whether treatment modifies mortality risk.
Cohort (n=323)
Are depression symptoms associated with increased all-cause mortality in patients receiving maintenance hemodialysis?
Hazard Ratio: 1.51 (95% CI 1.06–2.17)
Depression symptoms are associated with an increased risk of all-cause mortality in hemodialysis patients, highlighting the need to evaluate whether treating depression improves survival.
Fan et al. (2014) conducted a cohort in Hemodialysis (n=323). Depression (CES-D score ≥16) vs. No depression (CES-D score <16) was evaluated on All-cause mortality (HR 1.51, 95% CI 1.06-2.17). Baseline depression in hemodialysis patients was associated with an increased risk of all-cause mortality (HR 1.51; 95% CI 1.06-2.17), which attenuated after adjusting for comorbidities.
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