What question did this study set out to answer?

To develop a safe and efficient iridium(III)-catalyzed carbonylative cyclization method using a solid carbon monoxide surrogate to synthesize 2-quinolone derivatives.

August 16, 2026Organic Letters

Ir(III)-Catalyzed Carbonylative Cyclization of 2-AlkenylAnilines via Ex Situ Generation of CO: Access to2-Quinolone Derivatives

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To develop a safe and efficient iridium(III)-catalyzed carbonylative cyclization method using a solid carbon monoxide surrogate to synthesize 2-quinolone derivatives.
Employed an Ir(III) catalyst system alongside molybdenum hexacarbonyl [Mo(CO)6] as a CO source within a two-chamber reactor.
Combined experimental and computational mechanistic analyses to elucidate and optimize the transformation pathway.
Demonstrated synthetic applicability through the construction of bioactive 2-quinolone derivatives.
Successfully achieved carbonylative cyclization of 2-alkenylanilines to generate 2-quinolones without requiring pressurized carbon monoxide gas.
Validated the reaction mechanism computationally and experimentally while successfully synthesizing targeted bioactive molecules.

Implication

Experimental study demonstrates safe synthesis of 2-quinolones via Ir(III)-catalyzed carbonylation using ex situ carbon monoxide, highlighting applications in bioactive molecule design.

Abstract

Herein, we describe a novel method for the synthesis of 2-quinolones through Ir(III)-catalyzed carbonylative cyclization of 2-alkenyl anilines. The use of Mo(CO)6 as a CO surrogate, together with a two-chamber reactor system, enables safe and efficient access to these compounds. Experimental and computational mechanistic investigations guided the rational development of this transformation. The synthetic potential of this method is further demonstrated by the synthesis of bioactive compounds.

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Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a817a11f2fb91fc834ad983 https://doi.org/10.1021/acs.orglett.6c02640

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Implication

Experimental study demonstrates safe synthesis of 2-quinolones via Ir(III)-catalyzed carbonylation using ex situ carbon monoxide, highlighting applications in bioactive molecule design.

Ir(III)-Catalyzed Carbonylative Cyclization of 2-AlkenylAnilines via Ex Situ Generation of CO: Access to2-Quinolone Derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Ir(III)-Catalyzed Carbonylative Cyclization of 2-AlkenylAnilines via Ex Situ Generation of CO: Access to2-Quinolone Derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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