Observational study examines large vessel disease and stroke risk in CADASIL, highlighting the clinical relevance of large artery involvement in hereditary small vessel disease.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), caused by NOTCH3 pathogenic variants, is the most prevalent hereditary small vessel disease. While primarily affecting penetrating arteries, the clinical significance of concomitant large vessel disease (LVD) remains uncertain. We investigated LVD prevalence, its correlation with neuroimaging markers, and its role in predicting previous and incident stroke.
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Sung et al. (2026) studied this question.
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