What question did this study set out to answer?

To evaluate the electrophysiological and functional properties of anterior cingulate cortex pyramidal neurons in a mouse model of Prader-Willi syndrome with paternal Snord116 deletion.

August 16, 2026The Journal of PhysiologyOpen Access

Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader‐Willi syndrome

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To evaluate the electrophysiological and functional properties of anterior cingulate cortex pyramidal neurons in a mouse model of Prader-Willi syndrome with paternal Snord116 deletion.
Assessed dendritic complexity, synaptic connectivity, resting membrane potential, and firing properties of pyramidal neurons in the anterior cingulate cortex of Snord116-deficient mice versus controls.
Interrogated published genomic datasets to identify candidate genes and downstream signaling pathways responsible for the observed functional neuronal alterations.
Pyramidal neurons in Snord116-deficient mice showed higher dendritic complexity and stronger afferent excitatory connectivity compared to wild-type controls.
Strong excitatory input was balanced by a more hyperpolarized resting membrane potential, reduced somatic excitability, improved signal-to-noise discrimination, and increased low-pass filtering.
Genomic profiling implicated voltage-gated potassium and sodium channels, protein kinases, phosphatases, and the mTOR intracellular signaling pathway in mediating the phenotype.

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Implication

Experimental mouse study demonstrates altered pyramidal neuron electrophysiology in the anterior cingulate cortex, suggesting enhanced reward-seeking circuitry in Prader-Willi syndrome.

Cite This Study

Rybalchenko et al. (2026) studied this question.

synapsesocial.com/papers/6a817a21f2fb91fc834adbc1 https://doi.org/10.1113/jp290255

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Implication

Experimental mouse study demonstrates altered pyramidal neuron electrophysiology in the anterior cingulate cortex, suggesting enhanced reward-seeking circuitry in Prader-Willi syndrome.

Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader‐Willi syndrome

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Discussion

Implication

Cite This Study

Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader‐Willi syndrome

Key Points

Discussion

Implication

Cite This Study