Population
Isolated pressurised rat mesenteric arteries, portal vein, and uterine tissues
Comparison
Cytochalasin D or latrunculin B vs Control (untreated)
Design
Preclinical
Authors
Loading...
Actin disruption may decouple force from calcium in animal vessels; hypothesis-generating for cytoskeletal targets, with no clinical translation yet.
Inhibitors of actin polymerisation attenuate agonist-induced force responsiveness without reducing intracellular calcium in smooth muscle tissues, suggesting actin dynamics regulate contractile state independently of calcium homeostasis.
Shaw et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: