Effect of disruption of the cytoskeleton on smooth muscle contraction

View Full Paper

Ask AI

Bookmark

Population

Aortic rings (vascular smooth muscle)

Design

Preclinical

Authors

Discussion

Hypothesis-generating for cytoskeletal role in vascular smooth muscle; does not inform clinical practice.

Population

Aortic rings (vascular smooth muscle)

Intervention

Cytoskeleton disruption via colchicine, cytochalasin B, cooling/warming, or antisense oligonucleotide to kinesin

Outcome

Contractile response (active force generation) to stimulation at different levels of stretchsurrogate

Microtubules and actin filaments of the cytoskeleton play an active role in the slow force development of vascular smooth muscle contraction.

BATTISTELLA-PATTERSON et al. (1997) studied this question.

View Full Paper

Ask AI

Bookmark