What question did this study set out to answer?

To formulate and characterize eugenol-loaded microparticles using a ternary biopolymer matrix and assess their in vitro antibacterial efficacy against clinically relevant bacterial strains.

August 16, 2026PharmaceuticalsOpen Access

Spray-Dried Eugenol Microparticles: Physicochemical Characterization and Enhanced Antibacterial Activity

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Authors

VÁVicenta Albarral Ávila ANAnna Nardi-Ricart ACAitor Caballero-Román

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Overview

In vitro experimental study demonstrates enhanced antibacterial potency of spray-dried eugenol microparticles against bacterial pathogens, indicating promise for topical antimicrobial formulations.

Key Points

To formulate and characterize eugenol-loaded microparticles using a ternary biopolymer matrix and assess their in vitro antibacterial efficacy against clinically relevant bacterial strains.
Formulated microparticles from an emulsion of maltodextrin, gum arabic, and soy lecithin via spray drying.
Characterized product recovery, morphology via SEM, particle size via laser diffraction, and encapsulation efficiency via GC-FID.
Evaluated antibacterial activity against eight bacterial strains using agar well diffusion and broth microdilution to determine minimum inhibitory concentrations (MIC) compared to free eugenol.
Spray drying produced smooth, spherical microparticles under 20 µm in diameter, achieving a product recovery of 61.88% and an encapsulation efficiency of 52.45%.
Microencapsulation reduced MIC values by 4- to 16-fold compared with free eugenol across susceptible Gram-positive and Gram-negative pathogens.
The microparticle formulation demonstrated potent antibacterial efficacy across most test strains, though Pseudomonas aeruginosa remained resistant to both free and encapsulated eugenol.

Cite This Study

Ávila et al. (2026) studied this question.

synapsesocial.com/papers/6a817a33f2fb91fc834ade5d https://doi.org/10.3390/ph19081285

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August 16, 2026PharmaceuticalsOpen Access

Spray-Dried Eugenol Microparticles: Physicochemical Characterization and Enhanced Antibacterial Activity

View Full Paper

Ask AI

Bookmark

Authors

VÁVicenta Albarral Ávila ANAnna Nardi-Ricart ACAitor Caballero-Román

Discussion

Member takes

Overview

In vitro experimental study demonstrates enhanced antibacterial potency of spray-dried eugenol microparticles against bacterial pathogens, indicating promise for topical antimicrobial formulations.

Key Points

To formulate and characterize eugenol-loaded microparticles using a ternary biopolymer matrix and assess their in vitro antibacterial efficacy against clinically relevant bacterial strains.
Formulated microparticles from an emulsion of maltodextrin, gum arabic, and soy lecithin via spray drying.
Characterized product recovery, morphology via SEM, particle size via laser diffraction, and encapsulation efficiency via GC-FID.
Evaluated antibacterial activity against eight bacterial strains using agar well diffusion and broth microdilution to determine minimum inhibitory concentrations (MIC) compared to free eugenol.
Spray drying produced smooth, spherical microparticles under 20 µm in diameter, achieving a product recovery of 61.88% and an encapsulation efficiency of 52.45%.
Microencapsulation reduced MIC values by 4- to 16-fold compared with free eugenol across susceptible Gram-positive and Gram-negative pathogens.
The microparticle formulation demonstrated potent antibacterial efficacy across most test strains, though Pseudomonas aeruginosa remained resistant to both free and encapsulated eugenol.

Cite This Study

Ávila et al. (2026) studied this question.

synapsesocial.com/papers/6a817a33f2fb91fc834ade5d https://doi.org/10.3390/ph19081285

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