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August 16, 2026Infection and ImmunityOpen Access

Transcriptional analyses of peripheral blood lymphocytes obtained shortly after primary immunization discriminate vaccines against Francisella tularensis

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Authors

RPRoberto De PascalisSEScott EspichHKHamda Khan

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Overview

Animal study reveals distinct gene expression signatures differentiating tularemia vaccine candidates in rats, indicating early transcriptional biomarkers predict protective efficacy.

Key Points

  • To evaluate and compare early post-immunization cellular and transcriptional immune responses elicited by two Francisella tularensis vaccine candidates.
  • Immunized Fischer 344 rats with either the standard live vaccine strain (LVS) or a novel live attenuated Type A-derived strain (ΔclpB).
  • Assessed immune responses shortly after primary immunization using humoral assays, flow cytometry of peripheral blood leukocytes, and relative gene expression analysis.
  • Humoral immune responses were comparable between rats vaccinated with LVS and those receiving ΔclpB.
  • Transcriptional profiling revealed significant differential gene expression at selected post-vaccination time points between the two vaccines, predicting distinct activation and inhibition patterns across biological pathways.

Cite This Study

Pascalis et al. (2026) studied this question.

synapsesocial.com/papers/6a817a33f2fb91fc834adea7https://doi.org/10.1128/iai.00208-26
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Also Consider

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  1. 1A panel of correlates predicts vaccine-induced protection of rats against respiratory challenge with virulent Francisella tularensis2018 · 23 citations
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