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Post-mortem pathology in a fatal case of neuroleptic malignant syndrome suggests a peripheral myopathic mechanism for hyperthermia rather than a central one.
The neuroleptic malignant syndrome is a rare but dangerous complication of treatment with neuroleptics. The aetiology and pathophysiology of the syndrome are reviewed, and a fatal case is presented where both brain and muscle pathology are described. Striking myopathic changes in this case, accompanied by only minimal and non-specific brain abnormalities, support a peripheral rather than central mechanism for the hyperthermia.
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Jones et al. (1989) studied this question.
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