Neuroleptic malignant syndrome: Successful treatment with dantrolene and bromocriptine

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Why the study?

Does parenteral dantrolene and high-dose bromocriptine improve symptoms of neuroleptic malignant syndrome?

Population

1 patient with chronic schizophrenia treated with fluphenazine who developed neuroleptic malignant syndrome

Design

Case_report

Authors

Discussion

Supports dantrolene plus bromocriptine for NMS in one case; hypothesis-generating and should not change practice.

Does parenteral dantrolene and high-dose bromocriptine improve symptoms of neuroleptic malignant syndrome?

Population

1 patient with chronic schizophrenia treated with fluphenazine who developed neuroleptic malignant syndrome

Intervention

Parenteral dantrolene and high doses of bromocriptine

Outcome

Correction of hyperthermia, elevated serum creatine kinase, obtundation, rigidity, and tremulousness

Parenteral dantrolene and high-dose bromocriptine were effective in treating a case of neuroleptic malignant syndrome.

Granato et al. (1983) studied this question.

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