Key result
An endovascular cooling device rapidly corrected severe hyperthermia refractory to standard cooling and dantrolene in a patient with neuroleptic malignant syndrome, leading to recovery.
Why the study?
Does an endovascular cooling device improve hyperthermia in a patient with neuroleptic malignant syndrome refractory to standard cooling?
Case Report (n=1)
Does an endovascular cooling device improve hyperthermia in a patient with neuroleptic malignant syndrome refractory to standard cooling?
Endovascular cooling may be an effective rescue therapy for severe, refractory hyperthermia in neuroleptic malignant syndrome.
May warrant consideration in refractory NMS hyperthermia; single-case evidence leaves open need for prospective trials.
We report a patient with neuroleptic malignant syndrome who presented with the characteristic features of altered mental state, hyperthermia, haemodynamic dysregulation, elevated creatine kinase and subsequently increased muscle rigidity. The hyperthermia was refractory to standard cooling techniques and dantrolene but was rapidly corrected using an endovascular cooling device. He recovered from this life-threatening condition but required ongoing renal replacement support following discharge from the intensive care unit.
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Mathieu et al. (2010) conducted a case report in Neuroleptic malignant syndrome with severe hyperthermia (n=1). Endovascular cooling device vs. Standard cooling techniques and dantrolene was evaluated on Correction of hyperthermia and recovery. An endovascular cooling device rapidly corrected severe hyperthermia refractory to standard cooling and dantrolene in a patient with neuroleptic malignant syndrome, leading to recovery.
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