December 1, 1977Psychiatry and Clinical Neurosciences

Malignant Neuroleptic Syndrome—Its Present Status in Japan and Clinical Problems

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Population

14 patients who developed malignant neuroleptic syndrome during neuroleptic drug therapy in Japan

Design

Case_series

Authors

HIHitoshi ItohTokai University Hospital NONobuo OhtsukaKeio University KOKazuhiro OgitaThe University of Tokyo

Discussion

Member takes

Implication

May warrant caution with parenteral incisive neuroleptics in exhausted or dehydrated patients; leaves open confirmation in larger prospective studies.

Structured PICO

Population

14 patients who developed malignant neuroleptic syndrome (hyperpyrexia, akinesia, mutism, extrapyramidal symptoms, and severe autonomic symptoms) during neuroleptic drug therapy in Japan

Intervention

Neuroleptic drug therapy (including parenteral administration of incisive type agents)

Outcome

Clinical features and pathogenic factors of malignant neuroleptic syndromesafety

Physical exhaustion, dehydration, and parenteral administration of incisive neuroleptic agents are potential risk factors for developing malignant neuroleptic syndrome.

Cite This Study

Itoh et al. (1977) studied this question.

synapsesocial.com/papers/6a817a40e83875aedff092a7 https://doi.org/10.1111/j.1440-1819.1977.tb00127.x

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Implication

May warrant caution with parenteral incisive neuroleptics in exhausted or dehydrated patients; leaves open confirmation in larger prospective studies.

Malignant Neuroleptic Syndrome—Its Present Status in Japan and Clinical Problems

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Malignant Neuroleptic Syndrome—Its Present Status in Japan and Clinical Problems

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider