What question did this study set out to answer?

To characterize acid-base disorders in dogs with hyperlactatemia using traditional and semiquantitative methods, while determining hyperlactatemia mechanisms and the prognostic value of metabolic acidosis.

August 16, 2026Journal of Veterinary Emergency and Critical CareOpen Access

Retrospective Evaluation of Acid–Base Disorders in Dogs With Hyperlactatemia Using Traditional and Semiquantitative Analysis: 3866 Cases

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Authors

LSLaurence M. Saint‐PierreUniversity of Utah SESteven E. EpsteinUniversity of California, Davis KHKate HopperUniversity of California, Davis

Discussion

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Implication

Retrospective study reveals high mortality linked to metabolic acidosis in dogs with hyperlactatemia, indicating the diagnostic utility of semiquantitative acid–base analysis.

Key Points

To characterize acid-base disorders in dogs with hyperlactatemia using traditional and semiquantitative methods, while determining hyperlactatemia mechanisms and the prognostic value of metabolic acidosis.
Retrospective analysis of N=3866 hospitalized dogs with plasma lactate >2 mmol/L evaluated with traditional acid-base analysis at a university teaching hospital.
Semiquantitative acid-base evaluation conducted on a subset of N=1755 dogs with complete biochemical profiles.
Gastrointestinal disease was the most common associated condition (1232/3866 [29.3%]), and circulatory shock was the leading cause of hyperlactatemia (741/3866 [19.1%]).
Semiquantitative evaluation revealed concurrent acidifying and alkalinizing effects in 1241 of 1755 dogs (70.7%), driven predominantly by unmeasured anions in 775 dogs (44.1%).
Metabolic acidosis was associated with significantly increased mortality (682/1452 [46.9%]) compared to patients without metabolic acidosis (479/2414 [19.8%], p < 0.001), with type A hyperlactatemia conferring higher mortality than type B (52.5% vs 30.4%, p < 0.001).

Cite This Study

Saint‐Pierre et al. (2026) studied this question.

synapsesocial.com/papers/6a817a4cf2fb91fc834ae0be https://doi.org/10.1111/vec.70148

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Implication

Retrospective study reveals high mortality linked to metabolic acidosis in dogs with hyperlactatemia, indicating the diagnostic utility of semiquantitative acid–base analysis.

Retrospective Evaluation of Acid–Base Disorders in Dogs With Hyperlactatemia Using Traditional and Semiquantitative Analysis: 3866 Cases

Discussion

Member takes

Implication

Key Points

Cite This Study

Retrospective Evaluation of Acid–Base Disorders in Dogs With Hyperlactatemia Using Traditional and Semiquantitative Analysis: 3866 Cases

Discussion

Member takes

Implication

Key Points

Cite This Study

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