Review demonstrates how the metabolome controls cellular energy and substrate balance across tissues, highlighting therapeutic targets for metabolic disorders.
The metabolome regulator is an integrative system that controls the concentrations of energy substrates (glucose, fatty acids, amino acids, ketone bodies, lactate) and the ratio of ATP/ADP, NAD⁺/NADH in all tissues of the body. anabolism and catabolism, quantitative parameters (substrate concentrations, ATP/ADP ratios, NAD⁺/NADH, mitochondrial density). The effect on twenty meta-environments of the body has been shown. Pathological conditions in imbalance (insulin resistance, metabolic syndrome, type 2 diabetes mellitus, obesity, chronic fatigue syndrome) and correction methods (intermittent fasting, ketogenic diet, physical activity, microbiome modulation, pharmacological agents) are considered.
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Лагода (2026) studied this question.
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