What question did this study set out to answer?

To formulate and evaluate sustained-release matrix tablets containing Emblica officinalis (Amla) hydroalcoholic extract for prolonged management of peptic ulcer disease.

August 16, 2026Open Access

"Formulation & Evaluation of Sustained Release Dosage Form on Anti-Ulcer Treatment Using Emblica Officinalis."

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Authors

MJMiss. Pooja D.Jadhav, Miss. Priya M. Dandekar, Akshay G. Ghule, Amol jadhav

Discussion

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Overview

Formulation study demonstrates sustained diffusion-controlled release of Emblica officinalis extract over 12 to 24 hours, suggesting an effective herbal approach for peptic ulcer management.

Key Points

To formulate and evaluate sustained-release matrix tablets containing Emblica officinalis (Amla) hydroalcoholic extract for prolonged management of peptic ulcer disease.
Extracted bioactive compounds from authenticated Emblica officinalis fruits using a hydroalcoholic solvent system and performed phytochemical standardization.
Formulated matrix tablets via direct compression using polymers including HPMC K15M/K100M, Carbopol 934, and ethylcellulose.
Assessed physicochemical properties (weight variation, hardness, friability, thickness, drug content uniformity) and analyzed in vitro dissolution kinetics over 12–24 hours.
Tablets demonstrated satisfactory mechanical and physicochemical properties, including acceptable hardness, low friability, and uniform drug content.
In vitro dissolution testing revealed a sustained extract release profile extending across 12 to 24 hours.
Drug release kinetics predominantly followed the Higuchi and Korsmeyer–Peppas models, indicating a diffusion-controlled mechanism from the polymer matrix.

Cite This Study

Miss. Pooja D.Jadhav, Miss. Priya M. Dandekar, Akshay G. Ghule, Amol jadhav (2026) studied this question.

synapsesocial.com/papers/6a817a4cf2fb91fc834ae110 https://doi.org/10.5281/zenodo.21933105

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August 16, 2026Open Access

"Formulation & Evaluation of Sustained Release Dosage Form on Anti-Ulcer Treatment Using Emblica Officinalis."

View Full Paper

Ask AI

Bookmark

Authors

MJMiss. Pooja D.Jadhav, Miss. Priya M. Dandekar, Akshay G. Ghule, Amol jadhav

Discussion

Member takes

Overview

Formulation study demonstrates sustained diffusion-controlled release of Emblica officinalis extract over 12 to 24 hours, suggesting an effective herbal approach for peptic ulcer management.

Key Points

To formulate and evaluate sustained-release matrix tablets containing Emblica officinalis (Amla) hydroalcoholic extract for prolonged management of peptic ulcer disease.
Extracted bioactive compounds from authenticated Emblica officinalis fruits using a hydroalcoholic solvent system and performed phytochemical standardization.
Formulated matrix tablets via direct compression using polymers including HPMC K15M/K100M, Carbopol 934, and ethylcellulose.
Assessed physicochemical properties (weight variation, hardness, friability, thickness, drug content uniformity) and analyzed in vitro dissolution kinetics over 12–24 hours.
Tablets demonstrated satisfactory mechanical and physicochemical properties, including acceptable hardness, low friability, and uniform drug content.
In vitro dissolution testing revealed a sustained extract release profile extending across 12 to 24 hours.
Drug release kinetics predominantly followed the Higuchi and Korsmeyer–Peppas models, indicating a diffusion-controlled mechanism from the polymer matrix.

Cite This Study

Miss. Pooja D.Jadhav, Miss. Priya M. Dandekar, Akshay G. Ghule, Amol jadhav (2026) studied this question.

synapsesocial.com/papers/6a817a4cf2fb91fc834ae110 https://doi.org/10.5281/zenodo.21933105

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