Just mix to get six: Six contiguous stereocenters, including one quaternary stereocenter, and three CC bonds are created by a new copper-catalyzed tandem reaction (see scheme). Rigid chiral diamine ligands enabled this asymmetric tandem reaction to proceed with excellent stereoselectivity (complete diastereoselectivity and high enantioselectivity) and high yield under mild reaction conditions.
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Shi et al. (2011) studied this question.
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